Endocrine Abstracts

Introduction: Abnormalities in cell cycle pathways, such as CDKN1B (p27) underexpression, have been identified in the pathogenesis of pituitary adenomas, but their underlying mechanisms have not been elucidated. Ribosomal proteins have been recently related to pituitary tumorigenesis. In gastric cancer, RPS13 down-regulates p27 and promotes cell cycle progression; these mechanisms have not yet been explored in pituitary adenomas.Objective: To evaluate th...

There is a clinical spectrum of non-classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (NC-CAH). In addition, CYP21A2 gene mutations analysis present in homozygosis or as compound heterozygosis.Objectives: To evaluate the relationship between the genotype and biochemical profiles and also compare with clinical severity in NC-CAH.Patients and methods: Clinical, hormonal and molecular data of 57 patien...

Background: Low plasma aldosterone after adrenalectomy due to aldosterone-producing adenoma (APA) and postoperative hypoaldosteronism recovery have been well described. However, prospective time course comparing simultaneously aldosterone and renin levels is still lacking.Aim: We prospectively studied clinical and biochemical findings emphasizing aldosterone and renin levels, in a cohort of patients with APA who underwent adrenalectomy in a single tertia...